Jeffrey aube - Possible relatives for Andrew Eiferle include Kathleen Eiferle, Timothy Aube, Jeff Aube and several others. An associated email address for Andrew Eiferle is aeife***@compuserve.com. A phone number associated with this person is (810) 629-0089, and we have 2 other possible phone numbers in the same local area codes 810 and 517.

 
A method for the optical resolution of carboxylic acids is described. Condensation of racemic carboxylic acids with chiral terminal propargyl alcohols gave separable diastereomeric esters. Chromatographic separation followed by heating the individual diastereomers in methanol with catalytic copper(I) halide regenerated the carboxylic acids in good yields and in enantiomeric ratios of ≥94% .... 6 foot pencil tree

Jeff Aube Memoriam Jeff Aube11/29/1959 11/24/2020 Forever in our Hearts and Forever in our Family -Lori and The Brezinas Published by Connecticut Post on Nov. 24, 2021.Clinical trials targeting bromodomains and registered on ClinicalTrials.gov (National Library of Medicine and National Institutes of Health, United States), as of 1 January 2015.Jeffrey Kube Jeff Aube. related to Sharon Majewski Scott Mccullough, 60 Judy Anderson, 78 Lori Anderson, 49 James Scudder, 57 Katie Kube K Knautz. has lived in Trevor, WI McHenry, IL Fox River Grove, IL Genoa City, WI ... What is Jeffrey Kube's date of birth? Jeffrey Kube was born on 1973.Assistant Professor, 1986–1992 . Leader, Drug Discovery, Development, and Experimental Therapeutics division, KU Cancer Center, 2012–2014. Member, KU …View the profiles of professionals named "Jeffrey Aube" on LinkedIn. There are 10+ professionals named "Jeffrey Aube", who use LinkedIn to exchange information, ideas, and opportunities. Organic azides : syntheses and applications. Authors: Stefan Bräse, Klaus Banert. Summary: Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applicationsThe number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new ...Read Principles of Asymmetric Synthesis by Robert E. Gawley,Jeffrey Aube with a free trial. Read millions of eBooks and audiobooks on the web, iPad, iPhone and Android.Tumor suppressor ARID1A, a subunit of the chromatin remodeling complex SWI/SNF, regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents genomic instability. In addition, ARID1A has been shown to foster resistance to cancer therapy. By promoting non-homologous end joining (NHEJ), ARID1A enhances DNA repair. Consequently, ARID1A has been proposed as a promising ...Jeff Aube. UNC Chapel Hill USA Zachary T. Ball. Rice University USA Andre Beauchemin. University of Ottawa Canada Simon Blakey. Emory University USA LC Campeau. Merck USA Paul Chirik. Princeton University USA Martin Conda-Sheridan. University of Nebraska Medical Center, Omaha ...Xu, Liang; Aube, Jeffrey / University of Kansas Lawrence: NIH 2018 R01 CA: Molecular cancer therapy targeting HuR-ARE interaction Xu, Liang; Aube, Jeffrey / University of Kansas Lawrence: NIH 2017 R01 CA: Molecular cancer therapy targeting HuR-ARE interaction Xu, Liang; Aube, Jeffrey / University of Kansas Lawrence: $432,001: NIH 2016 R01 CAHFIP in Organic Synthesis: A Comprehensive Review of its Applications and Mechanisms. This article provides a detailed overview of the diverse roles of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent, reagent, catalyst, and additive in organic synthesis, covering more than 500 examples from the literature. The article also discusses the physicochemical properties, spectroscopic features ...Jeffrey Aube [...] Alison Axtman; Introduction: The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the AMP-AD program. Methods: A cheminformatics-driven effort ...Jeffrey M Aube, age --, lives in Rochester, NY. View their profile including current address, phone number (585) 442-XXXX, background check reports, and property record on Whitepages, the most trusted online directory.Jeffrey Aube University of Kansas. John Hershberger UW Madison. William F Tracy Emory. Mary T. MacDonald University of Kansas. Pankaj N. Desai University of Kansas. Jennifer E. Golden UW Madison + Aaron D. Wrobleski University of Kansas. Christopher E. Katz University of Kansas. Weston R. Judd University of Kansas. Scott A. GrecianJeffrey Aubé works at University of North Carolina at Chapel Hill, which is a Colleges & Universities company with an estimated 12,961 employees. J effrey is currently based in United States. Found email listings include: @unchealth.unc.edu. Read …Jeffrey Aube. Professor . University of North Carolina at Chapel Hill. Phone Email. Nick Aube. Founder . Phone Email. Kim Aube. Energy Director, Global Operations . ... Nina Aube is a Sculptor and Concept Illustrator - Hallmark Keepsake Ornaments at Hallmark Cards based in Kansas City, Missouri. Previously, Nina was a Keepsake Artist at ...Several related techniques to effect the synthesis of optically active heterocycles are proposed. These methods, which involve the use of diastereotopic group selectivity, can be separated into two ge...Jun 20, 2023 · Jeffrey L Aube is 52 years old and lives in Lewiston, Maine. Jeffrey was born in June 1971. Jeffrey has 3 different addresses, the most recent of which is in Lewiston, Maine. Associated Addresses. 52 gloria ave, lewiston, ME 04240 52 king ave, lewiston, ME 04240 77 bernie hartford rd, leeds, ME 04263 Show More (+) Contact Jeff directly. Join to view full profile. View Jeff Aubé's profile on LinkedIn, the world's largest professional community. Jeff has 1 job listed on their profile. See the complete profile on LinkedIn and discover Jeff's connections and jobs at similar companies.508. 2001. Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. A Fribley, Q Zeng, CY Wang. Molecular and cellular biology 24 (22), 9695-9704.Jeffrey Aubé's 406 research works with 9,842 citations and 9,277 reads, including: HuR-dependent expression of Wisp1 is necessary for TGFβ-induced cardiac myofibroblast activity ... Jeffrey Aube ...The following list of United States Synthetic Organic Faculty was originally compiled by Professor Matt McIntosh, University of Arkansas and was called Organiclinks. He created the list in the late 1990’s and maintained it for 20+ years for the members of his group and those of the organic community. The Links here are provided as a service ...Organic azides : syntheses and applications. Authors: Stefan Bräse, Klaus Banert. Summary: Most current state-of-the-art overview of this important class of compounds, encompassing many new and emerging applicationsThe number of articles on organic azides continues to increase tremendously; on average, there are more than 1000 new ...Jeffrey T. Aube Area Facilities Engineer, Lafata Contract Services, LLC Cornish, ME. Connect Gregory Ranft, P.E. Jersey City, NJ. Connect Thomas Hatton Greater Brisbane Area ...Research Mentor: Jeffrey Aube, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy Program: SOLAR & SURE Research Title: Triazoles as Kappa Opioid Agonists. The United States opioid epidemic is caused, in part, due to the available opioid pain relievers having adverse effects like euphoria. One …Biography. Stéphan Aubé started to study piano at the age of five. He studied at the Conservatoire à Rayonnement Régional of Boulogne-Billancourt, where he won first …Kristine FRANK | Cited by 485 | of AbbVie, Illinois (ABBVIE) | Read 21 publications | Contact Kristine FRANKin Business Management from Arizona State University. External Advisory Board Members. Dr. Jeffrey Aube Professor Jeff Aube Research Page · [email protected] of Asymmetric Synthesis This pageintentionallyleftblank Principles of Asymmetric Synthesis Second Edition Robert E. Gawley Department ofChemistry and Biochemistry Universityof Arkansas Fayetteville, AR USA and Jeffrey Aube´ DepartmentofMedicinal Chemistry Universityof Kansas Lawrence, KS USA AMSTERDAM(cid:129)BOSTON(cid:129)HEIDELBERG(cid:129)LONDON(cid:129)NEWYORK(cid:129)OXFORD ...Jeffrey Aube, 44 Summerville, SC Reputation Score: 2.73 - 3.98 Michell Clarke, 46 Summerville, SCCorresponding Author. Prof. Jeffrey Aubé. [email protected]; Department of Medicinal Chemistry, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA)Jack Aube. Title: Archeaologist. Company: The College Of William & Mary. Coworkers: John Christophersen, Dandan Jin, Valerie Philbrick Debrava, Matt Gutridge, Yunan Zhang. 6 records for Jack Aube. Find Jack Aube's phone number, address, and email on Spokeo, the leading online directory for contact information.Liked by Jeffrey Aube Last week, I had the opportunity to attend Sigma Chi Fraternity's Horizons Leadership Summit. Throughout the week, we developed our leadership skills… 1,2,4-Triazines are a class of heterocyclic compounds that have shown promising activity against G-quadruplex DNA, a potential target for anticancer drugs. In this article, the authors explore the structure-activity relationship of various 1,2,4-triazine derivatives and identify some potent and selective inhibitors of G-quadruplex formation.Derek Bain. Ecole Sec Theriault. Class of 1982. Joh Baleck. Timmins High & Voc School. Class of 1986. Alejandro Ball. Ogorman High School. Amanda Banfield.Gurpreet Singh, Angelica Meyer, and Jeffrey Aubé* Department of Medicinal Chemistry, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 Abstract Protected 4-hydroxycyclopentenones (4-HCPs) constitute an important class of intermediates in chemical synthesis.“Twisted” amides containing nonstandard dihedral angles are typically hypersensitive to hydrolysis, a feature that has stringently limited their utility in water. We have synthesized a series of bridged lactams that contain a twisted amide linkage but exhibit enhanced stability in aqueous environments. Many of these compounds were extracted unchanged from aqueous mixtures ranging from the ... Lorenzo Allegri, Federica Baldan, Sudeshna Roy, Jeffrey Aubé, Diego Russo, Sebastiano Filetti, Giuseppe Damante. The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. ... Joshua B. Benoit, Jeffrey Aube, Liang Xu, Michael Tranter. Activation of HuR downstream of p38 MAPK promotes cardiomyocyte ...vi Contents 2.2.6 TetrabutylammoniumAzide (TBAA) 35 2.2.7 Others 37 2.3 Examples for the UseofAzides on aTechnical Scale 37 2.3.1 Addition ofNaN,to Multiple CC- or CN-Bonds 37 2.3.2 Addition ofAlk-N3 andAr-N, to Multiple CC-and/or CN-Bonds 43 2.3.3 CarboxylicAcidAzides: Precursors for Isocyanates 43 2.3.4 OrganicAzides: Ring …Jeff Aubé, PhD, is a UNC Lineberger Comprehensive Cancer Center member and UNC Eshelman School of Pharmacy faculty as a Distinguished Professor for the Center for Integrative Chemical Biology and Drug Discovery and Professor in the UNC Department of Chemistry.Postdoc - 2010 - 2014 - University of Kansas, Specialized Chemistry Center (Mentor: Jeffrey Aube) Research. Twitter - @flahertylab. Lab Website - www.flahertylab.com. The Flaherty Lab pursues projects to validate novel therapeutic targets for the treatment of infectious disease, chronic pain, and cancer. At our core, we are a medicinal ...View Jeffrey Aube's business profile as Senior Project Manager at HMT. Find contact's direct phone number, email address, work history, and more.Chemistry, Biology. Nature Communications. 2022. TLDR. A Schmidt-type reaction where aryldiazonium salts act as the nitrogen precursor and in-situ-generated cyclopenta-1,4-dien-1-yl acetates serve as pronucleophiles from gold-catalyzed Nazarov cyclization of 1,3-enyne acetates is shown. 4.Create a free family tree for yourself or for Jeffrey Aube and we'll search for valuable new information for you. Get started U.S. Public Records Index. Jeffrey L Aube 1971 Jeffrey L Aube, born 1971. Jeffrey L Aube was born on month day 1971. Jeffrey lived at address. He lived at address.Jeffrey Aube City of Stockton Public Works Department 22 E. Weber Avenue, Room 301 Stockton, Ca 95202-1997 Reference: Proposal to Provide Professional Engineering Services for updates to the Stockton Traffic Management System Configuration Report and Traffic Signal Design and Operations Guide Dear Mr. Aube and Project Selection Committee, Operations Vice President & Director at Hamilton Connections. Anthony joined Hamilton Connections in 1998 as an intern and became a full-time recruiter in 2000 after graduating from Clark University with a bac helor's degree in business management and economics. He was promoted to branch manager in 2002 and opened the East Hartford, CT office.The University of Kansas (KU) has a history of success in synthetic medicinal chemistry that continues to the present day. NIH investments in these activities have included a Chemical Methodologies an...Possible relatives for Jeffrey Antle include Brian Antle, Patrick Wilson, Jeff Antle and several others. An associated email address for Jeffrey Antle is jeffrey.an***@yahoo.com . A phone number associated with this person is (941) 498-0767 , and we have 5 other possible phone numbers in the same local area codes 941 and 816 .Principles of Asymmetric Synthesis, Second Edition by Robert E. Gawley, Jeffrey Aube. 2012 | ISBN: 0080448607 | English | 568 pages | PDF + EPUB | 75 MB + 15 MB. The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale ...Looking for Jeff Aube? Found 15 people named Jeff Aube along with free Facebook, Instagram, Twitter, and TikTok profiles on PeekYou - true people search.Upregulation of an RNA-binding protein HuR has been implicated in glomerular diseases. Herein, we evaluated whether it is involved in renal tubular fibrosis. Zhimin Huang, Simeng Liu, Anna Tang, Xiaoqing Wu, Jeffrey Aube, Liang Xu and Yufeng Huang. Journal of Translational Medicine 2023 21 :428.Research Mentor: Jeffrey Aube, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy Program: SOLAR & SURE Research Title: Triazoles as Kappa Opioid Agonists. The United States opioid epidemic is caused, in part, due to the available opioid pain relievers having adverse effects like euphoria.Principles of Asymmetric Synthesis. The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a ...The most recent tenant is William Marshall.Past residents include Geoffery Aube, Florence Mcgrail, Catherine Powell, Mary Stahl and Jeffrey Aube.FastPeopleSearch results provide address history, property records, and contact information for current and previous tenants.The University of Kansas (KU) has a history of success in synthetic medicinal chemistry that continues to the present day. NIH investments in these activities have included a Chemical Methodologies an...Aubé, Jeffrey. November 6, 2017. Our lab develops new chemistry, and chemical agents as biological probes and drug discovery candidates. Current interests include the discovery of unconventional opioid agents, anti-tuberculosis drugs, and basic biochemistry of androgen biosynthesis inhibitors.Jeffrey Aube City of Stockton Public Works Department 22 E. Weber Avenue, Room 301 Stockton, Ca 95202-1997 Reference: Proposal to Provide Professional Engineering Services for updates to the Stockton Traffic Management System Configuration Report and Traffic Signal Design and Operations Guide Dear Mr. Aube and Project Selection Committee,Jeffrey Aubé, PhD Fred Eshelman Distiguished Professor UNC Eshelman School of Pharmacy Jointly Appointed Professor of Chemistry Jeffrey Aubé received a BS in chemistry from the University of Miami in 1980. He was a James B. Duke Fellow and C.R. Hauser Fellow at Duke University, where he studied with Steven W. Baldwin and earned a PhD in 1984.He is in his fifties. The age of Jeffrey is fifty-five. Jeffrey's current address is 317 Forest Str, Monessen, PA 15062-1312. This address is also linked to Jeff Nartowicz and Nancy Nartowicz. Jeffrey has phone numbers (724) 684-4790 (Verizon Pennsylvania, Inc), (412) 334-3477 (Cellco PartnershipVerizon Pennsylvania, Inc).Jeffrey Aube Andrea Morales 4570-000-800007-300-000-30-45- 000-000- please provide full account number Publication Information / Account: 2099378863 Requested Publication Date(s) Bid Opening OR Meeting Date 3/31, 4/7,4/14 3/31/22 Text for Publication in NOTICE INVITING BIDS The City of Stockton, California, will receive sealed bids until Thursday,A pilot randomized trial of video-based family therapy for home-visited mothers with perinatal depressive symptoms. The role of Akt signaling in prefrontal circuit function and cognitive impairment. High-Resolution Dynamic Imaging of Ovarian Cancer Metastasis Post Chemotherapy. Novel causal inference methods to inform clinical …JEFFREY AUBE CITY OF STOCKTON 22 E. WEBER AVENUE, ROOM 301 STOCKTON, CA 95202 The proposal should be firmly sealed in an envelope which will clearly be marked on the outside with "LIGHTED CROSSWALK UPGRADES" for the City of Stockton (Project No. PWI 526). The Cost Proposal must be in a sealed envelope separate from the proposal.Year. Recipient. Year. Recipient. 1944. Lucuas P. Kyrides. 1983. Jacob Kleinberg. 1945. Carl F. Cori & Gerty T Cori. 1984. Norman Cromwell. 1946. Anderson W Ralstgn. 1985Gloria Aube, 67 Jeffrey Aube, 49 Laura Aube, 35 Angel Aube, 38 Krystallynn Aube. has lived in Suffolk, VA Newport News, VA Hampton, VA Norton Shores, MI. Joseph M Aube. Age 38 / Apr 1985. View Profile. Tacoma, WA. also known as Joseph Aube Joesph Aube. related to Renee Davis, 37 Ryan Davis, 35 Aube Davis Kristene Aube, 62 Steven Aube, 61.Jeffrey Aube . Research Animal Specialist at Massachusetts General Hospital . Jeffrey Aube is a Research Animal Specialist at Massachusetts General Hospital based in Boston, Massachusetts. Read More . Contact. Jeffrey Aube's Phone Number and Email Last Update. 11/24/2022 1:58 PM. Email.Browse Spring Hill local obituaries on Legacy.com. Find service information, send flowers, and leave memories and thoughts in the Guestbook for your loved one.2uestion 5 continued. c) In the construction of a library of substituted 2-arylpiperidines, Jeffrey Aube used the regioselective ring opening of the cyclic epoxide below for the selective addition of nitrogen to the pyrrolidine ring. In this work: (i) Nucleophilic ring opening of the epoxide below with sodium azide gave a product azido-alcohol ...The American Association of Colleges of Pharmacy (AACP) announced UNC Eshelman School of Pharmacy Professor Jeff Aubé as the recipient of the AACP …Jeffrey Aubé, Marlys Hammond, Elyse Gherardini, and Fusao Takusagawa, Journal of Organic Chemistry , 1991 , 56 , 499–508. Correction : J. Org. Chem. 1991 , 56 ,Nicholas J. Klus3, Jeffrey Aube´ ID 4, Wendy Cox5, Kim L. R. Brouwer2 1 Center for Innovative Pharmacy Education and Research, Division of Practice Advancement and Clinical Education, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, NorthJeffrey Aube Product Analyst at Rochester Institute of Technology. 4mo Report this comment Congratulations Eli! Excited to see where this takes you! Like Reply ...A popular high school teacher and long-time volleyball coach on trial for sexual assault admitted he "tapped the behind" of a female colleague in a teacher's lounge in 2017, but he and the ...125 Mason Farm Road. CB# 7363. Chapel Hill, NC 27599. Department profile. Jeff Aubé, PhD, is a UNC Lineberger Comprehensive Cancer Center member and UNC Eshelman School of Pharmacy faculty as a Distinguished Professor for the Center for Integrative Chemical Biology and Drug Discovery and Professor in the UNC Department of Chemistry. Jeffrey Aube. University of North Carolina. 確認したメール アドレス: unc.edu. Chemistrymedicinal chemistry. 論文引用先オープン アクセス共著者 ...Jeffrey Aube; The intramolecular Schmidt reaction of alkyl azides and ketones has been demonstrated. The reaction is proposed to occur via initial attack of an azide on a ketone activated by a ...Jeff Aube has had a busy year.The Kansas University professor of medicinal chemistry has helped to lead a new specialized chemistry center that is charting new molecules in the fight against ...Jeffrey Aube has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO). HCV helicase inhibitors and methods of use thereof. Patent number: ...Jeffrey Aubé, Yuguang Wang, Marlys Hammond, Mehmet Tanol, Fusao Takusagawa, and David Vander Velde, Journal of the American Chemical Society, 1990, 112, 4879-4891. 12. "Directed Regiochemical Control in the Ring Expansion Reactions of a Substituted trans- Decalone." Jeffrey Aubé and Marlys Hammond, Tetrahedron Letters, 1990, 31, 2963- 2966.You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect. Li Y, Tran AH, Danishefsky SJ, et al. (2019) Chemical biology of glycoproteins: From chemical synthesis to biological impact.Methods in Enzymology. 621: 213-229: Brailsford JA, Stockdill JL, Axelrod AJ, et al. (2018) Total ...

Jeffrey Aube [...] Alison Axtman; Introduction: The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the AMP-AD program. Methods: A cheminformatics-driven effort .... What is a communications plan

jeffrey aube

Jeffrey Aube Receives the Edward Leete Award. August 7, 2017. Edward Leete Award Purpose To recognize outstanding contributions to teaching and research in Organic Chemistry Nature The award will be presented no more than biennially during the fall national meeting of the American Chemical Society. The Award consists of a …Jennifer E. Golden. Jennifer received her B.S. in Chemistry from Eastern Illinois University (1996), followed by a Ph.D. in Medicinal Chemistry while working with Professor Jeffrey Aube at the University of Kansas (2002). Following her postdoctoral work at Stanford University with Professor Paul Wender (2004), she joined Amgen in the division ...Jeffrey S Aube, Jeff S Aube, Jeff Aube, Jeffrey Stephen Aube. GRAND BLANC HIGH SCHOOL. 810-***-**** View Phone. 9 Visits. Photos. Not the right Jeffrey? View More. LOW HIGH. 0 Add Rating Anonymously. 0 Reputation Score Range. 2.48 4.53 /5. View Actual Score Check Background ...The most recent tenant is Geoffrey Crall.Past residents include Stephen Kessler, Margaret Kambish, Twyla Murphy, Angela Barker and Jeffrey Aube.FastPeopleSearch results provide address history, property records, and contact …AubéLabUNC is the research group of Jeffrey Aubé, a distinguished professor of pharmacy and chemistry at UNC. The group focuses on synthetic organic chemistry, medicinal chemistry, and chemical biology. Visit the group page to learn more about their projects, publications, and members.Gutierrez O, Aubé J, Tantillo DJ. Mechanism of the acid-promoted intramolecular schmidt reaction: theoretical assessment of the importance of lone pair-cation, cation-π, and steric effects in controlling regioselectivity. The Journal of Organic Chemistry. 77: 640-7. PMID 22126337 DOI: 10.1021/Jo202338M. 28 thg 10, 2019 ... "La Loire – Aube et crépuscule" ... The films Jeffrey Blondes is presenting at the Domain of Chaumont-sur-Loire are the result of regularly and ...Eric Langholtz Life, Long Term Care & Health Insurance - (954) 608-4678 Find Jeffrey Aube in Grand Blanc Mi 48439. Fast and Free! Get current address, phone, email and more for Jeffrey Aube in Grand Blanc Mi 48439 or anyone else 100% freWe found 10 entries for Jeffrey Aube in the United States. The name Jeffrey Aube has over 10 birth records, 0 death records, 0 criminal/court records, 36 address records, 7 phone records & more. The construction of nitrogen heterocycles is vital for the synthesis of biologically important agents. This grant concerns the development of several new methods for lactam synthesis using ring-expans....

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